Leptin-deficient mice have altered three-dimensional growth plate histomorphometry
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چکیده
منابع مشابه
Altered sleep regulation in leptin-deficient mice.
Recent epidemiological, clinical, and experimental studies have demonstrated important links between sleep duration and architecture, circadian rhythms, and metabolism, although the genetic pathways that interconnect these processes are not well understood. Leptin is a circulating hormone and major adiposity signal involved in long-term energy homeostasis. In this study, we tested the hypothesi...
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Suppressor of cytokine signalling-2 (SOCS2) negatively regulates the signal transduction of several cytokines. Socs2(-/-) mice show increased longitudinal skeletal growth associated with deregulated GH/IGF-1 signalling. The present study examined the role of SOCS2 in endochondral ossification and trabecular and cortical bone formation, and investigated whether pro-inflammatory cytokines associa...
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An analysis of heat transfer in the flow of a viscous, in-compressible fluid along an infinite porous plate is presented when the plate is subjected to a transverse sinusoidal suction. The flow field becomes three-dimensional due to this type of suction velocity. Expressions for the flow and temperature fields are obtained by series expansion method. It is found during the course of discussion ...
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Nonalcoholic fatty liver disease (NAFLD) is strongly linked to obesity, insulin resistance, and abnormal hepatic lipid metabolism; however, the precise regulation of these processes remains poorly understood. Here we examined genes and proteins involved in hepatic oxidation and lipogenesis in 14-week-old leptin-deficient Ob/Ob mice, a commonly studied model of obesity and hepatic steatosis. Obe...
متن کاملCALL FOR PAPERS Metabolic Syndrome Altered sleep regulation in leptin-deficient mice
Laposky, Aaron D., Jonathan Shelton, Joseph Bass, Christine Dugovic, Nicholas Perrino, and Fred W. Turek. Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol 290: R894–R903, 2006. First published November 17, 2005; doi:10.1152/ajpregu.00304.2005.—Recent epidemiological, clinical, and experimental studies have demonstrated important links between sleep durat...
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ژورنال
عنوان ژورنال: Diabetology & Metabolic Syndrome
سال: 2019
ISSN: 1758-5996
DOI: 10.1186/s13098-019-0402-5